| Autor: |
Ghodsi Mohammadi Ziarani, Shikofa Khorrami, Fatemeh Mohajer, Sunil V. Gaikwad, Najibullah Hassani, Alireza Badiei, Siavash Iravani, Rajender S. Varma |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 7, Iss , Pp 101362- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2024.101362 |
| Popis: |
In this study, an efficient copper (II) chemosensor was introduced. This chemosensor had a different response in fluorescent spectra, and the interaction between Cu2+ and tryptophan hydrazide (TH) was substantiated as a static quencher. In addition, there is a good relationship between the fluorescent intensity of tryptophan-based fluorescent and the concentration of Cu2+ ions with a detection limit of LOD = 24.32 x 10−5 M. The interference by many other cations was also evaluated, which was almost negligible. The docking calculation of this chemical with protein PDB: 5vc3 and PDB: 2xp2 protein PDB: 5vc3 and PDB: 2xp2 was performed, exhibiting significant anticancer potential as well. The present research also focused on the use of molecular docking calculation with a significant role in drug design. The protein three-dimensional (3D) structure of protein PDB: 5vc3 and PDB: 2xp2 were isolated from the protein data bank and docked with tryptophan derivatives. The docking results confirmed that the tryptophan derivatives had the best docking score −7.5–7.6 kcal/mol with PDB: 5vc3 and PDB: 2xp2 protein for breast cancer. The study demonstrated that this compound can function as both a chemosensor for the detection of metal ions and as a bioactive agent with potential anticancer properties. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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