| Autor: |
Junhua Wu, Wei Wang, Yang Liu, Jing Sun, Yan Ye, Bingyun Li, Xiaona Liu, Hongxu Liu, Zhenqi Sun, Mang Li, Jing Cui, Dianjun Sun, Yanmei Yang, Yanhui Gao |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 10, Iss 6, p e0128280 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0128280 |
| Popis: |
Brick tea type fluorosis is a public health concern in the north-west area of China. The association between SNPs of genes influencing bone mass and fluorosis has attracted attention, but the association of SNPs with the risk of brick-tea type of fluorosis has not been reported.To investigate the modifying roles of GSTP1 rs1695 polymorphisms on this association.A cross-sectional study was conducted. Brick-tea water was tested by the standard of GB1996-2005 (China). Urinary fluoride was tested by the standard of WS/T 89-2006 (China). Skeletal fluorosis was diagnosed by X-ray, the part we scheduled was forearm, shank, and pelvic, then diagnosed the skeletal fluorosis by the standard of WS/192-2008 (China). Gene polymorphism was tested by Sequenom MassARRAY system.The prevalence rate in different ethnical participants was different: Tibetan individuals had the highest prevalence rate of skeletal fluorosis. There were significant differences in genotype frequencies of GSTP1 Rs1695 among different ethnical participants (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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