Immunohistochemistry and next-generation sequencing for NTRK fusion detection in differentiated thyroid cancer of children, adolescents and young adults

Autor: Ana Clara Oliveira Tosta Telles, Gabriel Jeferson Rodríguez Machado, Juliana Lima von-Ammon, Rafael Reis Campos da-Matta, Taíse Lima Cerqueira de-Oliveira, Fabyan Esberard de Lima Beltrão, Alexandre Rolim da-Paz, Fabio Hecht, Guilherme de Castro Lopes, Leonardo Freitas Boaventura Rios, Bruno da Silva Lisboa, Helton Estrela Ramos
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Brazilian Journal of Oncology, Vol 20 (2024)
Druh dokumentu: article
ISSN: 2526-8732
DOI: 10.5935/2526-8732.20240456
Popis: Introduction: Pan-TRK immunohistochemistry staining can assess the protein expression from NTRK gene fusions. A little is known about its utility in differentiated thyroid cancer samples from children, adolescents, and young adults patients. Objective: Investigate pan-TRK immunohistochemistry sensitivity and specificity in differentiated thyroid cancer samples from children, adolescents, and young adults patients. Methods: Tumor samples obtained from 79 children, adolescents, and young adults patients (age
Databáze: Directory of Open Access Journals