Juvenile dermatomyositis: association between nail fold capillary end row loop– area under the curve– and disease damage indicators

Autor:	Amer Khojah, Gabrielle Morgan, Marisa S. Klein-Gitelman, Lauren M. Pachman
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Juvenile Dermatomyositis Nailfold vasculature Disease Activity scores Area under the curve Lipodystrophy Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935
Zdroj:	Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-8 (2023)
Druh dokumentu:	article
ISSN:	1546-0096
DOI:	10.1186/s12969-023-00919-3
Popis:	Abstract Background Juvenile Dermatomyositis (JDM) is a rare autoimmune disease characterized by skin and muscle inflammation. The loss of nail fold capillary end row loops (ERL) is evidence of small vessel involvement in JDM. This study aimed to examine the specific association of ERL over the disease course with evidence of JDM disease damage. Methods We analyzed data from 68 initially treatment-naïve JDM children who had been observed for at least five years with multiple ERL density assessments. The JDM disease course were categorized into monocyclic short, monocyclic long, polycyclic, and chronic. The ERL capillary count was cumulatively evaluated using the area under the curve (AUC) method. Results The mean ERL density for the treatment-naive JDM was significantly lower than that of their healthy age-matched controls (4.8 ± 1.6 /mm vs. 7.9 ± 0.9 /mm; p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c7acdad65fcb49b994bbb98c1899a0b7 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.