TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

Autor:	Estela Morales Peralta, Yaíma Zúñiga Rosales, Teresa Collazo Mesa, Elvia Nelmi Santos González, Yadira Hernández Pérez, María de los Ángeles González Torres, Hilda Roblejo Balbuena, Beatriz Marcheco Teruel
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	COVID-19 Genetic polymorphism Cuba Alleles Vitamin D Receptor Medicine (General) R5-920 Genetics QH426-470
Zdroj:	Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-4 (2021)
Druh dokumentu:	article
ISSN:	2090-2441
DOI:	10.1186/s43042-021-00206-4
Popis:	Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7abb50e1c3864dfdb07bcf809449c8c2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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