Modeling of the Effects of Turbulence Intensity on Mechanical Hemolysis of Red Blood Cells
| Autor: | Amir Omidvar, Hassan Khaleghi, Elham Amini |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | مجله دانشکده پزشکی اصفهان, Vol 29, Iss 174 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1027-7595 1735-854X |
| Popis: | Background: Mechanical hemolysis plays an important role in development of cardiovascular prostheses, artificial valves, and blood pumps. Considerable research has been conducted to investigate mechanical hemolysis of red blood cells (RBC). Most previous studies have focused on the effects of Reynolds number of blood flow and mean value of turbulent stresses. However, less attention has been paid to the influence of eddy length scale and turbulence intensity. Methods: In this study, a new analytical correlation was proposed in order to predict the mechanical hemolysis due to turbulence effects. The roles of Reynolds number and relative turbulence intensity were clearly demonstrated in the proposed correlation. The good agreement between predicted results and the experimental data showed that the proposed model had good accuracy. Findings: RBCs can tolerate up to 20% of turbulence intensity depending on the value of Reynolds number of the blood flow. In addition, the maximum endurable value of turbulence intensity of a human RBC decreases as Reynolds number of the blood flow increases. Conclusion: For the first time, this paper showed that mechanical hemolysis of RBC can be intensely influenced by the turbulence intensity of blood flow. Therefore, a simple explicit analytical criterion was proposed for prediction of the effects of turbulence intensity on mechanical hemolysis of RBC. |
| Databáze: | Directory of Open Access Journals |
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