Effect of carbamazepine-beta-cyclodextrin inclusion complex on seizure-like events in an in vitro model of temporal lobe epilepsy
| Autor: | Kiss Rita-Judit, Csüdör Ágnes, Sárosi Máté, Nagy Zsolt András, Szentes Ádám, Gáll Zsolt, Szilágyi Tibor, Orbán-Kis Károly |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Acta Marisiensis - Seria Medica, Vol 70, Iss 2, Pp 50-57 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2668-7763 2024-0007 |
| DOI: | 10.2478/amma-2024-0007 |
| Popis: | Objective: Pharmacoresistant epilepsy represents a significant global health challenge, necessitating novel therapeutic approaches. Despite advances in antiseizure medications, many patients remain treatment-resistant partially due to complex pharmacokinetic issues. Beta-cyclodextrin, known for enhancing drug solubility and stability, offers potential solutions by forming inclusion complexes, thereby improving anti-seizure medication’s efficacy. This study aimed to investigate the effect of beta-cyclodextrin and beta-cyclodextrin-complexed carbamazepine on epileptiform activities, using an in vitro model of temporal lobe epilepsy. |
| Databáze: | Directory of Open Access Journals |
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