| Autor: |
Dunđerski Jadranka S., Predić Jelena, Čvoro Aleksandra, Matić Gordana M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Archives of Biological Sciences, Vol 55, Iss 1-2, Pp 3-7 (2003) |
| Druh dokumentu: |
article |
| ISSN: |
0354-4664 |
| DOI: |
10.2298/ABS0302003D |
| Popis: |
This study was focused on Cd effects on basal and dexamethasone-induced tyrosine aminotransferase (TAT) activity in the rat liver cytosol. Cadmium (Cd), applied in the dose of 2 mg/kg b.w., stimulated both TAT activity and its induction by dexamethasone, inducing the most prominent alterations 24 h after administration. Doses lower than 2 mg Cd/kg b.w. were ineffective while the higher ones (3 and 4 mg Cd/kg b.w) led to the changes similar to those reached by 2 mg Cd/kg. The in vitro application of different Cd concentrations to the liver cytosol rendered the enzyme activity unchanged suggesting that the metal acted at the level of TAT gene transcription. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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