Antihypoxic Activities of Aerial Parts and Roots of Ferula persica in Mice
| Autor: | Ramin Ataee, Hedyeh Hasani, Mahsa Mohammadyan, Mohammad Ali Ebrahimzadeh |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 30, Iss 189, Pp 126-132 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: Hypoxia occurs in ischemia and heart attack, and leads to death. It involves production of reactive oxygen species. Antioxidants exhibit antihypoxic properties. Ferula persica has distinctive antioxidant activities. Nothing is known about the protective effect of this plant against hypoxia-induced lethality in mice. Materials and methods: Protective effects of methanolic extract of F. persica aerial parts and roots against hypoxia-induced lethality in mice were evaluated by experimental models of hypoxia, asphyctic, haemic, and circulatory. Results: Aerial parts showed a very good activity in asphyctic model and at 62.5 mg/kg the extract prolonged survival time (P< 0.05). At 250 mg/kg it showed the same activity as phenytoin. Root extract at 125 mg/kg prolonged survival time (P0.05). They showed the same activity as propranolol (P>0.05). Both extracts showed high activity in circulatory model and at 62.5 mg/kg they prolonged survival time (P |
| Databáze: | Directory of Open Access Journals |
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