The Effects of the SARS-CoV-2 Virus on the Cardiovascular System and Coagulation State Leading to Cardiovascular Diseases: A Narrative Review
| Autor: | Rafiq A. Bhat PhD, Syed Maqbool DM, DNB, FNB, Akanksha Rathi MD, Syed Manzoor Ali DM, Yoosuf Ali Ashraf Muhammad Hussenbocus MD, Xiao Wentao MD, Yongsheng Qu MD, You Zhang MD, Yuxiao Sun MD, Hai-Xia Fu MD, Ling Yun Wang MD, Atul Dwivedi PhD, Javaid Akhter Bhat PhD, Raja saqib Iqbal MD, Md Monowarul Islam MD, Abhishek Tibrewal MD, Chuanyu Gao PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Inquiry: The Journal of Health Care Organization, Provision, and Financing, Vol 59 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0046-9580 1945-7243 00469580 |
| DOI: | 10.1177/00469580221093442 |
| Popis: | The novel coronavirus pandemic has led to morbidity and mortality throughout the world. Until now, it is a highly virulent contagion attacking the respiratory system in humans, especially people with chronic diseases and the elderly who are most vulnerable. A majority of afflicted are those suffering from cardiovascular and coronary diseases. In this review article, an attempt has been made to discuss and thoroughly review the mode of therapies that alleviate cardiac complications and complications due to hypercoagulation in patients infected with the SARS-CoV-2 virus. Presently a host of thrombolytic drugs are in use like Prourokinase, Retelapse, RhTNK-tPA and Urokinase. However, thrombolytic therapy, especially if given intravenously, is associated with a serious risk of intracranial haemorrhage, systemic haemorrhage, immunologic complications, hypotension and myocardial rupture. The effects of the SARS-CoV-2 virus upon the cardiovascular system and coagulation state of the body are being closely studied. In connection to the same, clinical prognosis and complications of thrombolytic therapy are being scrutinized. It is noteworthy to mention that myocardial oxygen supply/demand mismatch, direct myocardial cells injury and acute plaque rupture are the multiple mechanisms responsible for acute coronary syndrome and cardiac complications in Covid-19 infection. However, this review has limitations as data available in this context is limited, scattered and heterogenous that questions the reliability of the same. So, more multi-centric studies involving representative populations, carried out meticulously, could further assist in responding better to cardiac complications among Covid-19 patients. |
| Databáze: | Directory of Open Access Journals |
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