| Autor: |
Doina TURCAN, Lucia ANDRIES, Alexandr DORIF, Victoria SACARA |
| Jazyk: |
English<br />French<br />Romanian; Moldavian; Moldovan<br />Russian |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
One Health & Risk Management, Vol 2, Iss 3, Pp 61-66 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2587-3466 |
| DOI: |
10.38045/ohrm.2021.3.10 |
| Popis: |
Introduction. Wiskott-Aldrich syndrome is a rare X-linked disorder characterized by microthrombocytopenia, eczema, and recurrent infections. It is caused by mutations of the WAS gene which encodes the WAS protein (WASp) – a key regulator of actin polymerization in hematopoietic cells. Mutations within the WASp gene result in a wide heterogeneity of clinical disease, ranging from ‘classical WAS’ to mild asymptomatic thrombocytopenia (X-linked thrombocytopenia [XLT]), or congenital neutropenia (X-lined neutropenia [XLN]). Case presentation. This present paper reports a phenotypical and laboratory description of two children diagnosed with WAS and one child diagnosed with XLT. The first case was a six months old male with septicemia, thrombocytopenia, eczema and petechial rash. The second case was a 2 years old boy presenting with complaints of recurrent infections, eczema and thrombocytopenia with small platelet size. The third case was a 16 years old boy who presented with thrombocytopenia and recurrent sinopulmonary infections. Conclusions. Due to a wide spectrum of clinical findings, the diagnosis of WAS/XLT should be considered in any male patient presenting with petechiae, bruises, and congenital or early-onset thrombocytopenia associated with small platelet size. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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