Epidemiology, clinical features, and management of severe hypercalcemia in critically ill patients

Autor:	Cyril Mousseaux, Axelle Dupont, Cédric Rafat, Kenneth Ekpe, Etienne Ghrenassia, Lionel Kerhuel, Fanny Ardisson, Eric Mariotte, Virginie Lemiale, Benoît Schlemmer, Elie Azoulay, Lara Zafrani
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Hypercalcemia (HCM) Onco-hematology Acute kidney injury (AKI) AKI etiology Renal replacement therapy (RRT) Kidney disease outcome Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	Annals of Intensive Care, Vol 9, Iss 1, Pp 1-10 (2019)
Druh dokumentu:	article
ISSN:	2110-5820
DOI:	10.1186/s13613-019-0606-8
Popis:	Abstract Background Severe hypercalcemia (HCM) is a common reason for admission in intensive-care unit (ICU). This case series aims to describe the clinical and biological features, etiologies, treatments, and outcome associated with severe HCM. This study included all patients with a total calcemia above 12 mg/dL (3 mmol/L) admitted in two ICUs from January 2007 to February 2017. Results 131 patients with HCM were included. HCM was related to hematologic malignancy in 58 (44.3%), solid tumors in 29 (22.1%), endocrinopathies in 16 (12.2%), and other causes in 28 (21.3%) patients. 108 (82.4%) patients fulfilled acute kidney injury (AKI) criteria. Among them, 25 (19%) patients required renal replacement therapy (RRT). 51 (38.9%) patients presented with neurological symptoms, 73 (55.7%) patients had cardiovascular manifestations, and 50 (38.1%) patients had digestive manifestations. The use of bisphosphonates (HR, 0.42; 95% CI, 0.27–0.67; P
Databáze:	Directory of Open Access Journals
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