Safety and efficacy of dexmedetomidine vs ketamine vs midazolam combined with propofol in gastrointestinal endoscopy for cancer patients: A randomized double-blinded trial
| Autor: | Nahla N Shehab, Walaa Y Elsabeeny, Sayed M Abed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Egyptian Journal of Anaesthesia, Vol 39, Iss 1, Pp 511-517 (2023) |
| Druh dokumentu: | article |
| ISSN: | 11101849 1110-1849 |
| DOI: | 10.1080/11101849.2023.2230404 |
| Popis: | ABSTRACTBackground A wide range of drugs are used for sedation in gastrointestinal (GI) endoscopy procedures, including midazolam, dexmedetomidine, and ketamine. Therefore, this study aimed to compare the effects of these drugs in combination with propofol among cancer patients undergoing GI endoscopy.Methods This randomized, double-blinded study was carried out on 75 cancer patients who underwent GI endoscopy. Patients were categorized into three equal groups. Group D: received dexmedetomidine 0.5 µg/kg bolus infusion over 10 min. Group K: received ketamine 0.5 mg/kg. Group M: received midazolam 0.05 mg/kg. With these drugs, 0.5 mg/kg propofol was administered intravenously with incremental 20 mg till achievement of Ramsey sedation score (RSS) 3–4. After that, 0.5 mg/kg propofol boluses were offered for rescue sedation.Results The endoscopy duration was comparable in the three groups. Time of RSS 3–4 achievement and total propofol dose (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|