RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression

Autor: Weipeng Mu, Noel S Murcia, Keriayn N Smith, Debashish U Menon, Della Yee, Terry Magnuson
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: G3: Genes, Genomes, Genetics, Vol 12, Iss 6 (2022)
Druh dokumentu: article
ISSN: 2160-1836
DOI: 10.1093/g3journal/jkac082
Popis: AbstractRBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive complex 2 and histone deacetylase 1/2-containing complexes. These complexes are responsible for histone H3 lysine 27 methylation and deacetylation, respectively. How RBBP4 modulates the functions of these complexes remains largely unknown. We generated viable Rbbp4Rbbp4
Databáze: Directory of Open Access Journals