Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies

Autor: Jie Gao, Liming Tao, Zhengxuan Jiang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Redox Report, Vol 28, Iss 1 (2023)
Druh dokumentu: article
ISSN: 13510002
1743-2928
1351-0002
DOI: 10.1080/13510002.2023.2272386
Popis: ABSTRACTObjectives This review outlines the function of oxidative stress in DR and discusses therapeutic strategies to treat DR with antioxidants.Methods Published papers on oxidative stress in DR and therapeutic strategies to treat DR with antioxidants were collected and reviewed via database searching on PubMed.Results The abnormal development of DR is a complicated process. The pathogenesis of DR has been reported to involve oxidative stress, despite the fact that the mechanisms underlying this are still not fully understood. Excessive reactive oxygen species (ROS) accumulation can damage retina, eventually leading to DR. Increasing evidence have demonstrated that antioxidant therapy can alleviate the degeneration of retinal capillaries in DR.Conclusion Oxidative stress can play an important contributor in the pathogenesis of DR. Furthermore, animal experiments have shown that antioxidants are a beneficial therapy for treating DR, but more clinical trial data is needed.
Databáze: Directory of Open Access Journals
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