| Autor: |
Nyla Ajaz, Ikram Ullah Khan, Muhammad Irfan, Syed Haroon Khalid, Sajid Asghar, Yasir Mehmood, Muhammad Asif, Usra, Ghulam Hussain, Yasser Shahzad, Shefaat Ullah Shah, Muhammad Usman Munir |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Gels, Vol 8, Iss 5, p 290 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2310-2861 |
| DOI: |
10.3390/gels8050290 |
| Popis: |
The current study reports the fabrication and biological evaluation of hydroxy propyl β-cyclodextrin-g-poly(acrylic acid)/gelatin (HP-β-CD-g-poly(AA)/gelatin) semi-interpenetrating networks (semi-IPN) for colonic delivery of dexamethasone sodium phosphate (DSP). The prepared hydrogels showed pH-dependent swelling and mucoadhesive properties. The mucoadhesive strength of hydrogels increased with an increasing concentration of gelatin. Based on the swelling and mucoadhesive properties, AG-1 was chosen as the optimized formulation (0.33% w/w of gelatin and 16.66% w/w of AA) for further analysis. FTIR revealed the successful development of a polymeric network without any interaction with DSP. SEM images revealed a slightly rough surface after drug loading. Drug distribution at the molecular level was confirmed by XRD. In vitro drug release assay showed pH-dependent release, i.e., a minute amount of DSP was released at a pH of 1.2 while 90.58% was released over 72 h at pH 7.4. The optimized formulation did not show any toxic effects on a rabbit’s vital organs and was also hemocompatible, thus confirming the biocompatible nature of the hydrogel. Conclusively, the prepared semi-IPN hydrogel possessed the necessary features, which can be exploited for the colonic delivery of DSP. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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