Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection

Autor: Katya Douchant, Shu-Mei He, Curtis Noordhof, Jill Greenlaw, Sarah Vancuren, Kathleen Schroeter, Emma Allen-Vercoe, Calvin Sjaarda, Stephen J. Vanner, Elaine O. Petrof, Prameet M. Sheth, Mabel Guzman
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-024-05778-6
Popis: Abstract Clostridioides difficile is the leading cause of antibiotic-associated infectious diarrhea. The development of C.difficile infection is tied to perturbations of the bacterial community in the gastrointestinal tract, called the gastrointestinal microbiota. Repairing the gastrointestinal microbiota by introducing lab-designed bacterial communities, or defined microbial communities, has recently shown promise as therapeutics against C.difficile infection, however, the mechanisms of action of defined microbial communities remain unclear. Using an antibiotic- C.difficile mouse model, we report the ability of an 18-member community and a refined 4-member community to protect mice from two ribotypes of C.difficile (CD027, CD078; p
Databáze: Directory of Open Access Journals
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