A Straightforward Diphenylmethyl Protection Method and Deprotection of Some Pyrimidine Nucleosides

Autor:	Arthur van Aerschot, Milind Saudi
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	hydroxyl protecting group palladium catalyst nucleoside diphenyl methyl Organic chemistry QD241-441
Zdroj:	Molecules, Vol 18, Iss 7, Pp 8524-8534 (2013)
Druh dokumentu:	article
ISSN:	18078524 1420-3049
DOI:	10.3390/molecules18078524
Popis:	Benzhydryl protection of primary and secondary alcohols has been reported previously via reaction with metal alcoholates. Our aim was to find generally useful and very mild conditions for the alcoholic protection and deprotection of nucleosides with the diphenylmethyl group. This was accomplished for some pyrimidine nucleosides using PdCl2 as the transition metal catalyst, and with optimization yields of 70–90% have been achieved. A lack of solubility of other nucleosides hampers its more general use.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7a3cb855e1964b21a42a8f36483e3b69 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF