| Autor: |
Anna Olewicz-Gawlik, Dorota Trzybulska, Barbara Kuznar-Kaminska, Katarzyna Katulska, Aleksandra Danczak-Pazdrowska, Halina Batura-Gabryel, Pawel Hrycaj |
| Jazyk: |
English<br />Spanish; Castilian<br />Portuguese |
| Předmět: |
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| Zdroj: |
Revista Brasileira de Reumatologia, Vol 56, Iss 4, Pp 309-313 |
| Druh dokumentu: |
article |
| ISSN: |
1809-4570 |
| DOI: |
10.1016/j.rbre.2015.07.005 |
| Popis: |
ABSTRACT Objective: To assess clinical utility of serum Clara cell 16-kDa protein measurements in relation with staging system for systemic sclerosis associated interstitial lung disease. Materials and methods: Serum levels of Clara cell 16-kDa protein were determined by ELISA in 28 systemic sclerosis patients and 30 healthy controls, and correlated with staging system for systemic sclerosis associated interstitial lung disease in systemic sclerosis patients. Lung involvement was assessed functionally (body plethysmography, diffusing capacity of the lung for carbon monoxide) and radiologically (an average disease extent on high resolution computed tomography of the lungs) in SSc patients. Results: We observed statistically significant differences in serum Clara cell 16-kDa protein levels between systemic sclerosis patients and healthy controls only in non-smokers. However, serum Clara cell 16-kDa protein concentrations were significantly elevated in patients with high resolution computed tomography extent >20% in comparison to patients with high resolution computed tomography extent |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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