Diagnostic and Prognostic Significance of Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) in Children with Bronchial Asthma
| Autor: | Yu.V. Odynets, Yu.V. Vasylchenko |
|---|---|
| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Zdorovʹe Rebenka, Vol 11, Iss 2.70, Pp 51-54 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2224-0551 2307-1168 |
| DOI: | 10.22141/2224-0551.2.70.2016.73808 |
| Popis: | To study the level of sVCAM-1 in children with bronchial asthma at different stages of the disease, we have examined 69 children aged from 6 to 17 years suffering from persistent bronchial asthma in exacerbation and remission and 15 apparently healthy children of the control group. We performed tourniquet test and determined the level of S-nitrozothiol in the blood serum to assess the endothelial function. Serum sVCAM-1 levels were studied using enzyme immunoassay. The presence of endothelial dysfunction in all children with bronchial asthma was detected. A significant increase in sVCAM-1 level in the blood serum was noted both in acute phase and during remission, indicating a long-term effect on the endothelium and formation of stable chronic inflammation. |
| Databáze: | Directory of Open Access Journals |
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