Retinal toxicity of long term overdose of sildenafil citrate: A case report

Autor: Huichao Yan, Wenzhen Yu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: American Journal of Ophthalmology Case Reports, Vol 29, Iss , Pp 101761- (2023)
Druh dokumentu: article
ISSN: 2451-9936
DOI: 10.1016/j.ajoc.2022.101761
Popis: Purpose: To report a case of eye structure changes in a patient with long-term overdose of sildenafil citrate. Observations: A 28-year-old male presented to our outpatient clinic with flare sensation in both eyes for 1 year after taking sildenafil citrate at a dose of 200 mg daily for two years. mERG and OCT examination revealed persistent damage of retinal photoreceptor cells. The symptoms did not disappear after 3 months off the medication. Conclusions and importance: Long term excessive use of overdose sildenafil citrate can cause serious damage to retinal photoreceptor cells. The retinal side effects of sildenafil citrate still need to be further investigated, and the administration of systemic overdose also needs to be considered by all physicians, not just ophthalmologists.
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