Crystal-Associated Colitis with Ulceration Leading to Hematochezia and Abdominal Pain

Autor: Meeta Desai, Aaron Reiprich, Nancy Khov, Zhaohai Yang, Abraham Mathew, John Levenick
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Case Reports in Gastroenterology, Vol 10, Iss 2, Pp 332-337 (2016)
Druh dokumentu: article
ISSN: 1662-0631
DOI: 10.1159/000446575
Popis: Lower GI bleeding is a common cause for hospitalization in adults. Medication-associated mucosal injury is an important clinical entity that can result in significant morbidity and mortality. We present the case of a 45-year-old woman with a 3-month history of intermittent abdominal cramping and rectal bleeding. Her medical history was extensive and included end-stage renal disease and a remote history of endometrial carcinoma that was treated with radiation. Initial workup was concerning for ischemic and radiation colitis, however, histology was most consistent with acute inflammation and ulceration associated with crystal fragments. Sevelamer and cholestyramine are commonly used ion-exchange resins that have been associated with mucosal damage. Both medications were discontinued and her symptoms resolved. Our case highlights an underrecognized but important cause of hematochezia.
Databáze: Directory of Open Access Journals
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