Lack of association between cortical amyloid deposition and glucose metabolism in early stage Alzheimer´s disease patients

Autor:	Ehrlich Daniela, Dunzinger Andreas, Malsiner-Walli Gertraud, Grün Bettina, Topakian Raffi, Hodolic Marina, Kainz Elmar, Pichler Robert
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	alzheimer disease pet tau fdg Medical physics. Medical radiology. Nuclear medicine R895-920
Zdroj:	Radiology and Oncology, Vol 56, Iss 1, Pp 23-31 (2021)
Druh dokumentu:	article
ISSN:	1581-3207 2021-0051
DOI:	10.2478/raon-2021-0051
Popis:	Beta amyloid (Aβ) causes synaptic dysfunction leading to neuronal death. It is still controversial if the magnitude of Aβ deposition correlates with the degree of cognitive impairment. Diagnostic imaging may lead to a better understanding the role of Aβ in development of cognitive deficits. The aim of the present study was to investigate if Aβ deposition in the corresponding brain region of early stage Alzheimer´s disease (AD) patients, directly correlates to neuronal dysfunction and cognitive impairment indicated by reduced glucose metabolism.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e7a28bdc0d2c4f90a0a4866cc53d7578 Zobrazit plný text záznamu View record in DOAJ