Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer

Autor:	Keeya Sunata, Tetsuo Tani, Takahiko Ui, Hidehiro Irie, Yohei Funatsu, Hidefumi Koh
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Diseases of the respiratory system RC705-779
Zdroj:	Case Reports in Pulmonology, Vol 2022 (2022)
Druh dokumentu:	article
ISSN:	2090-6854
DOI:	10.1155/2022/1160000
Popis:	Calcified bilateral mediastinal lymph nodes are not common in malignant tumors. A 51-year-old woman presented to our hospital with a 20 mm nodule in the lower left lobe of the lung and extensive calcification in the bilateral mediastinal lymph nodes. Computed tomography indicated no calcification of the primary lesion. Immunohistochemical staining and fluorescent in situ hybridization detected an anaplastic lymphoma kinase (ALK) fusion. Treatment with alectinib, an ALK inhibitor, led to a significant reduction in tumor size and calcification in the lymph nodes. This case shows that different degrees of calcification can be associated with malignant tumors and may be reversible in some cases.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7a2849e02814410e97ee5f9a15e75bb6 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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