The association between inflammatory bowel disease and risk of prostate cancer: a population-based retrospective study based on Korean National Health Insurance Service database
| Autor: | Gyoohwan Jung, Byeongdo Song, Jung Kwon Kim, Hasung Kim, Jungkuk Lee, Sung Kyu Hong |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Prostate International, Vol 12, Iss 3, Pp 139-144 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2287-8882 10720030 |
| DOI: | 10.1016/j.prnil.2024.05.001 |
| Popis: | Background: The aim of this study was to determine whether inflammatory bowel disease (IBD) is associated with the risk of developing prostate cancer (PCa) through a population-based study. Materials and methods: Male patients aged ≥40 years, diagnosed with IBD from 2010 to 2013 and without IBD were identified and followed-up till 2019. A matched cohort of male patients with and without IBD in a ratio of 1:4 was created based on age, income level, and Charlson comorbidity index. Multivariate Cox regression analysis was conducted to evaluate the association of IBD with the prescence of PCa and PCa requiring definitive treatment within 1 year of diagnosis. The hazard ratio (HR) and 95% confidence interval (CI) were stratified by Crohn's disease, ulcerative colitis (UC), and subtypes. Results: After matching, 15,751 IBD patients and 62,346 controls were analyzed. Over a median follow-up period of 96 months, the HR for PCa was significantly increased in patients with IBD (HR: 2.44; 95% CI: 2.08–2.86, P |
| Databáze: | Directory of Open Access Journals |
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