Childhood Stiff-Person Syndrome Improved with Rituximab
| Autor: | R. Fekete, J. Jankovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Case Reports in Neurology, Vol 4, Iss 2, Pp 92-96 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1662-680X 00033944 |
| DOI: | 10.1159/000339446 |
| Popis: | Introduction: Stiff-person syndrome (SPS) is manifested by fluctuating rigidity of axial musculature with painful episodic spasms due to simultaneous co-contraction of agonist and antagonist muscles. We present a case report and video illustrating response to treatment with rituximab. Materials and Methods: Case description and video are provided. A literature search for other reports of treatment with rituximab was performed. Results: Nine cases in addition to our case were described. Substantial clinical benefit was reported in 7/9 (78%) cases. Four out of 9 (44%) cases displayed persistent anti-glutamic acid decarboxylase (GAD) antibody positivity. Conclusion: Rituximab is an important treatment strategy in SPS. The persistence of anti-GAD antibody positivity even with clinical remission remains to be elucidated. |
| Databáze: | Directory of Open Access Journals |
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