| Popis: |
Background The prevalence of metabolic syndrome (MS) among the middle-aged and elderly population in China increases with age, serum uric acid to high density lipoprotein cholesterol ratio (UHR) is closely associated with various metabolic diseases, however, there are few studies on the relationship between UHR and MS in middle-aged and elderly people. Objective To explore the correlation between UHR and MS in middle-aged and elderly people in China, and evaluate the predictive value of UHR for MS. Methods This study used public data from the 2015 China Health and Retirement Longitudinal Survey (CHARLS) and included 9 233 subjects. General data, physical examination indexes and blood biochemical examination indexes were collected from the study subjects and their UHR was calculated. The subjects were divided into the non-MS group (n=7 006) and MS group (n=2 227) according to whether they had MS. At the same time, the subjects were divided into the Q1 group (UHR≤7.32%, n=2 308), Q2 group (7.32%12.20%, n=2 308) according to the level of the quartiles of UHR. Pearson correlation analysis was used to explore the correlation between UHR and metabolic indexes. The relationship between UHR and MS was studied by multivariate Logistic regression analysis. The receiver operating characteristic (ROC) curves for the risk of MS predicted by UHR in the overall and by different genders were plotted separately and the areas under the ROC curve (AUC) were calculated. Results The average age of the subjects was (60.3±9.6) years. The proportion of females, age, urban household proportion, history of hypertension, diabetes and dyslipidemia, proportion of taking lipid-lowering drugs, glycated hemoglobin, C-reactive protein, triglyceride (TG), total cholesterol (TC), fasting plasma glucose (FPG), SUA, systolic blood pressure (SBP), diastolic blood pressure (DBP), BMI, waist circumference (WC) and UHR in the MS group were higher than the non-MS group, while HDL-C, low-density lipoprotein cholesterol (LDL-C) and estimated glomerular filtration rate (eGFR) were lower than those in the non-MS group, and there were statistically significant differences in education level, smoking and alcohol consumption between the two groups (P |
