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Pengfei Zhang,1 Meng Zhang,1 Renfang Han,2 Kaiping Zhang,3 Huayang Ding,1 Chaozhao Liang,1 Li Zhang1 1Department of Urology, The First Affiliated Hospital of Anhui Medical University and Institute of Urology, Anhui Medical University, Hefei, China; 2Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China; 3Department of Urology, Anhui Provincial Children’s Hospital, Hefei, China Background: Although miR-221/222 cluster plays an important role in many human malignancies, the correlation between miR-221/222 cluster overexpression and tumor prognosis remains controversial. Therefore, an updated meta-analysis was conducted to clarify its prognostic value in malignancy.Methods: We conducted a search of literature in English electronic databases of PubMed, Embase, and Cochrane Library, and Chinese electronic databases of China Biology Medicine disc and China National Knowledge Infrastructure to obtain appropriate studies. Besides, we extracted hazard ratios (HRs) and 95% CIs to evaluate the strength of the correlations. In addition, the results of different subgroups analyses and publication bias test were also shown in this article.Results: 32 publications, including 15 tumor types and 2,693 patients were embraced in this meta-analysis. The results of univariate (HR =1.69, 95% CI: 1.18–2.44, P |
