Immune biomarkers for prognosis and prediction of responses to immune checkpoint blockade in cutaneous melanoma

Autor:	Nicolas Jacquelot, Jonathan M. Pitt, David P. Enot, Maria Paula Roberti, Connie P. M. Duong, Sylvie Rusakiewicz, Alexander M. Eggermont, Laurence Zitvogel
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	immune biomarkers immunotherapy melanoma predictive factors prognostic factors Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 6, Iss 8 (2017)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2017.1299303
Popis:	Existing clinical, anatomopathological and molecular biomarkers fail to reliably predict the prognosis of cutaneous melanoma. Biomarkers for determining which patients receive adjuvant therapies are needed. The emergence of new technologies and the discovery of new immune populations with different prognostic values allow the immune network in the tumor to be better understood. Importantly, new molecules identified and expressed by immune cells have been shown to reduce the antitumor immune efficacy of therapies, prompting researchers to develop antibodies targeting these so-called “immune checkpoints”, which have now entered the oncotherapeutic armamentarium.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c79e6bff49d74b6fbe3298685cce8dde Zobrazit plný text záznamu View record in DOAJ