Solar radiation-assisted one-pot synthesis of 3-alkylated indoles under catalyst-free conditions

Autor: Mohammad Pirbaba, Rezvan Kardooni, Ali Reza Kiasat, Mohammad Sabaeian
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104609- (2023)
Druh dokumentu: article
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2023.104609
Popis: Solar radiation-assisted green approach was developed for the chemoselective synthesis of 3-alkylated indoles via Yonemitsu-type condensation under catalyst-free conditions. The desired products were formed by one-pot three-component reaction of indole, aromatic aldehydes, and β-dicarbonyl compounds in polyethylene glycol-400 (PEG-400). The scope and generality of the presented approach were extended by various aromatic aldehydes and CH activated compounds. Using non-volatile solvent and renewable energy resources, absence of any catalyst, energy conservation, and the selective production of heterodimer product instead of homodimer adducts such as bisindole or xanthine, increase the economic and environmental effectiveness of the present protocol.
Databáze: Directory of Open Access Journals