| Autor: |
Andrea Luengas‐Martinez, Dina Ismail, Ralf Paus, Helen S. Young |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Skin Health and Disease, Vol 4, Iss 6, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2690-442X |
| DOI: |
10.1002/ski2.471 |
| Popis: |
Abstract Background Vascular endothelial growth factor A (VEGF‐A)‐mediated angiogenesis is involved in the pathogenesis of psoriasis. VEGF‐A inhibitors are widely used to treat oncological and ophthalmological diseases but have not been used in psoriasis management. The molecular mechanisms underlying the effects of VEGF‐A inhibition in psoriatic skin remain unknown. Objectives To identify the genes and canonical pathways affected by VEGF‐A inhibition in non‐lesional and plaque skin ex vivo. Methods Total RNA sequencing was performed on skin biopsies from patients with psoriasis (n = 6; plaque and non‐lesional skin) and healthy controls (n = 6) incubated with anti‐VEGF‐A monoclonal antibody (bevacizumab, Avastin®) or human IgG1 isotype control for 12 h in serum‐free organ culture. Differentially expressed genes between paired control and treated samples with adjusted p‐values |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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