Characteristics and Outcomes of Patients With Aortic Stenosis and Chronic Kidney Disease

Autor: Krishna K. Patel, Shailee Y. Shah, Susana Arrigain, Stacey Jolly, Jesse D. Schold, Sankar D. Navaneethan, Brian P. Griffin, Joseph V. Nally, Milind Y. Desai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 3 (2019)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.118.009980
Popis: Background We sought to study longer term survival in patients with aortic stenosis (AS) and nondialysis chronic kidney disease (CKD). Methods and Results We studied 839 patients (aged 78±9 years and 51% male) with CKD and AS on echocardiogram from 2005 to 2012. Longer term all‐cause and cardiovascular mortality was compared with a CKD group without AS, propensity matched for age, sex, race, left ventricular ejection fraction and CKD stage. Cox models were used to evaluate all‐cause mortality and competing‐risks regression models censored at time of aortic valve replacement to evaluate cardiac mortality in patients with AS and CKD. Overall, 511 (61%), 252 (30%), and 76 (9%) patients had CKD stages 3a, 3b, and 4, respectively; 93% had hypertension, 28% had diabetes mellitus, and 37% had coronary artery disease. In total, 185 (22%) had mild AS, 355 (42%) had moderate AS, and 299 (36%) had severe AS (66 symptomatic). Patients with CKD and AS had higher cardiac and all‐cause mortality compared with controls with CKD and no AS (P
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