Dehydroepiandrosterone Supplementation May Benefit Women with Asthma Who Have Low Androgen Levels: A Pilot Study

Autor:	Nadzeya Marozkina, Joe Zein, Mark D. DeBoer, Laurie Logan, Laura Veri, Kristie Ross, Benjamin Gaston
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Asthma Dehydroepiandrosterone (DHEA) Lung function Diseases of the respiratory system RC705-779
Zdroj:	Pulmonary Therapy, Vol 5, Iss 2, Pp 213-220 (2019)
Druh dokumentu:	article
ISSN:	2364-1754 2364-1746
DOI:	10.1007/s41030-019-00101-9
Popis:	ABSTRACT Introduction Among individuals with severe asthma, FEV1 is low in individuals with low dehydroepiandrosterone (DHEA) sulfate (DHEAS) levels. In the Severe Asthma Research Program (SARP), no women with DHEAS > 200 μg/dL had an FEV1 60% predicted received 100 mg DHEA orally every 12 h for 2 weeks. Spirometry and DHEAS were measured at the initial visit and 2 weeks later, after completion of DHEA treatment. Based on our previous work, the primary outcome variable for this pilot study was post-albuterol spirometry in the low-DHEAS group. Subjects also continued their other routine asthma management. Results Serum DHEAS increased with DHEA treatment in women with starting DHEAS
Databáze:	Directory of Open Access Journals
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