Dehydroepiandrosterone Supplementation May Benefit Women with Asthma Who Have Low Androgen Levels: A Pilot Study
Autor: | Nadzeya Marozkina, Joe Zein, Mark D. DeBoer, Laurie Logan, Laura Veri, Kristie Ross, Benjamin Gaston |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Pulmonary Therapy, Vol 5, Iss 2, Pp 213-220 (2019) |
Druh dokumentu: | article |
ISSN: | 2364-1754 2364-1746 |
DOI: | 10.1007/s41030-019-00101-9 |
Popis: | ABSTRACT Introduction Among individuals with severe asthma, FEV1 is low in individuals with low dehydroepiandrosterone (DHEA) sulfate (DHEAS) levels. In the Severe Asthma Research Program (SARP), no women with DHEAS > 200 μg/dL had an FEV1 60% predicted received 100 mg DHEA orally every 12 h for 2 weeks. Spirometry and DHEAS were measured at the initial visit and 2 weeks later, after completion of DHEA treatment. Based on our previous work, the primary outcome variable for this pilot study was post-albuterol spirometry in the low-DHEAS group. Subjects also continued their other routine asthma management. Results Serum DHEAS increased with DHEA treatment in women with starting DHEAS |
Databáze: | Directory of Open Access Journals |
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