Differing prevalence of microcephaly and macrocephaly in male and female fetuses

Autor: Amalia M. Brawley, Eric W. Schaefer, Elizabeth Lucarelli, Serdar H. Ural, Cynthia H. Chuang, Wenke Hwang, Ian M. Paul, Carrie Daymont
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Global Women's Health, Vol 4 (2023)
Druh dokumentu: article
ISSN: 2673-5059
DOI: 10.3389/fgwh.2023.1080175
Popis: ObjectiveTo compare the proportion of female and male fetuses classified as microcephalic (head circumference [HC] 97th percentile) by commonly used sex-neutral growth curves.MethodsFor fetuses evaluated at a single center, we retrospectively determined the percentile of the first fetal HC measurement between 16 and 0/7 and 21–6/7 weeks using the Hadlock, Intergrowth-21st, and NICHD growth curves. The association between sex and the likelihood of being classified as microcephalic or macrocephalic was evaluated with logistic regression.ResultsFemale fetuses (n = 3,006) were more likely than male fetuses (n = 3,186) to be classified as microcephalic using the Hadlock (0.4% male, 1.4% female; odds ratio female vs. male 3.7, 95% CI [1.9, 7.0], p
Databáze: Directory of Open Access Journals