Histopathological Confirmation of Axonal Sprouting in Regenerative Peripheral Nerve Interface
| Autor: | Song Ho Chang, MD, PhD, Yuji Maenohara, MD, PhD, Jun Hirose, MD, PhD, Yasunori Omata, MD, PhD, Sayaka Fujiwara, MD, PhD, Nobuhiko Haga, MD, PhD, Masako Ikemura, MD, PhD, Taku Saito, MD, PhD, Sakae Tanaka, MD, PhD, Takumi Matsumoto, MD, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Plastic and Reconstructive Surgery, Global Open, Vol 12, Iss 6, p e5878 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2169-7574 00000000 |
| DOI: | 10.1097/GOX.0000000000005878 |
| Popis: | Summary:. Symptomatic neuroma represents a debilitating complication after major limb amputation. The regenerative peripheral nerve interface (RPNI) has emerged as a reproducible and practical surgery aimed at mitigating the formation of painful neuroma. Although previous animal studies revealed axonal sprouting, elongation, and synaptogenesis of proximal nerve stump within the muscle graft in RPNI, there is a lack of reports confirming these physiological reactions at the histopathological level in human samples. This report presents a case of below-knee amputation with RPNI due to foot gangrene resulting from polyarteritis nodosa. Subsequently, an above-knee amputation was necessitated due to the exacerbation of polyarteritis nodosa, providing the opportunity for histopathological examination of the RPNI site. The examination revealed sprouting, elongation, and existence of neuromuscular junction of the tibial nerve within the grafted muscle. To the best of our knowledge, this is the first report demonstrating axonal sprouting, elongation, and possibility of synaptogenesis of the nerve stump within the grafted muscle in a human sample. |
| Databáze: | Directory of Open Access Journals |
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