Relationship between high-frequency activity in the cortical sensory and the motor hand areas, and their myelin content

Autor: Leo Tomasevic, Hartwig Roman Siebner, Axel Thielscher, Fiore Manganelli, Giuseppe Pontillo, Raffaele Dubbioso
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Brain Stimulation, Vol 15, Iss 3, Pp 717-726 (2022)
Druh dokumentu: article
ISSN: 1935-861X
DOI: 10.1016/j.brs.2022.04.018
Popis: Background: The human primary sensory (S1) and primary motor (M1) hand areas feature high-frequency neuronal responses. Electrical nerve stimulation evokes high-frequency oscillations (HFO) at around 650 Hz in the contralateral S1. Likewise, transcranial magnetic stimulation (TMS) of M1 can evoke a series of descending volleys in the corticospinal pathway that can be detected non-invasively with a paired-pulse TMS protocol, called short interval intracortical facilitation (SICF). SICF features several peaks of facilitation of motor evoked potentials in contralateral hand muscles, which are separated by inter-peak intervals resembling HFO rhythmicity. Hypothesis: In this study, we tested the hypothesis that the individual expressions of HFO and SICF are tightly related to each other and to the regional myelin content in the sensorimotor cortex. Methods: In 24 healthy volunteers, we recorded HFO and SICF, and, in a subgroup of 20 participants, we mapped the cortical myelin content using the ratio between the T1- and T2-weighted MRI signal as read-out. Results: The individual frequencies and magnitudes of HFO and SICF curves were tightly correlated: the intervals between the first and second peak of cortical HFO and SICF showed a positive linear relationship (r = 0.703, p
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