Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report
| Autor: | Vajihe Marsusi, Ashraf Sadat Jamal, Maasoumeh Saleh, Behnaz Nouri |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Case Reports in Clinical Practice, Vol 6, Iss S1 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2538-2683 2538-2691 |
| Popis: | Thrombotic Thrombocytopenic Purpura (TTP) is an acute, rare, potentially life-threatening disorder presenting with thrombocytopenia, hemolytic anemia, and clinical consequences of microvascular thrombosis caused by a deficiency of ADAMS13 [1, 2]. The incidence of acquired TTP is approximately three cases per one million adults per year, based on the Oklahoma TTP-Hemolytic uremic syndrome (HUS) Registry [3]. Here, we present a case of TTP with persistent severely deficient ADAMS13 activity and recurrent relapses. She had a refractory relapse in the third trimester of pregnancy, complicated with superimposed severe preeclampsia and sepsis, and finally expired due to intracranial hemorrhage (ICH). |
| Databáze: | Directory of Open Access Journals |
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