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Abstract Background The inflammation plays a role in the pathophysiology of type‐2 diabetes progression, and the mechanism remains unclear. The systemic immune‐inflammation index (SII) is a novel inflammatory marker for type 2 diabetes patients and integrates multiple indicators in complete blood counts and routine blood tests. Aim Since there is no international diagnostic standard for dry eye disease (DED), this study uses low‐cost inflammatory blood biomarkers to investigate the correlation between SII and DM2–DED and determine the diagnosis indices of other biomarkers in DM2–DED. Methodology A case‐control retrospective analysis of totel patients n = 293 randomly selected and categorized into four groups: DED, DM2, DM2‐DED, and healthy subjects. Demographic and blood biomarker variables were classified as categorical and continuous variables. The platelet‐to‐lymphocyte ratio (PLR), lymphocytes‐to‐lymphocyte ratio, neutrophil‐to‐lymphocyte ratio (NLR), and SII were calculated platelet count multiply by NLR and analyzed for their correlation for all groups. Results Focusing on DM2‐DED patients was more common in females, 59.6%, than in males, 40.2%. The mean ages were 60.7 ± 11.85 years, a statistically significant difference with all groups. In the study group DM2‐DED, there was an increase in all blood markers compared to all remaining groups except PLR. Only neutrophil, hemoglobin A1c (HbA1c), and fasting blood sugar levels were statistically significant differences in DM2‐DED patients (p > 0.001, p |
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