Management of pediatric keratoconus - Evolving role of corneal collagen cross-linking: An update
| Autor: | Vardhaman P Kankariya, George D Kymionis, Vasilios F Diakonis, Sonia H Yoo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Epidemiology
keratoconus prevalence Disease pathogenesis genetic heterogeneity genetics and genomics genome-wide association study genomic loci linkage mapping molecular mechanisms whole exome-genome sequencing Deregulation ectasia gene expression mass spectroscopy proteomics signaling pathways Cornea crosslinking modulus Corneal topography imaging optical coherence tomography placido disc based topography Ectatic disease scheimpflug imaging Keratoconus ocular allergy vernal keratoconjunctivitis Contact lens piggy back contact lenses rigid gas permeable scleral lens SynergEyes toric soft contact lens Corneal cross-linking techniques new technologies riboflavin Collagen cross linking Corneal collagen cross-linking hypoosmolar riboflavin thin cornea transepithelial collagen cross-linking Corneal cross-linking radiant exposure ultraviolet-A Accelerated corneal cross linking corneal laser surgery corneal ectasia UV light Laser in situ keratomileusis surgery very high fluence collagen cross-linking corneal ectosia LASIK ectosia prophylaxis Cornea collagen cross linking long term results Corneal collagen cross linking corneal transplant pediatric keratoconus Ophthalmology RE1-994 |
| Zdroj: | Indian Journal of Ophthalmology, Vol 61, Iss 8, Pp 435-440 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0301-4738 1998-3689 |
| DOI: | 10.4103/0301-4738.116070 |
| Popis: | Pediatric keratoconus demonstrates several distinctive management issues in comparison with adult keratoconus with respect to under-diagnosis, poor compliance and modifications in treatment patterns. The major concerns comprise of the accelerated progression of the disease in the pediatric age group and management of co-morbidities such as vernal keratoconjuntivitis. Visual impairment in pediatric patients may affect social and educational development and overall negatively impact their quality of life. The treatment algorithm between adults and pediatric keratoconus has been similar; comprising mainly of visual rehabilitation with spectacles, contacts lenses (soft or rigid) and keratoplasty (lamellar or penetrating) depending on the stage of the disease. There is a paradigm shift in the management of keratoconus, a new treatment modality, corneal collagen crosslinking (CXL), has been utilized in adult keratoconic patients halting the progression of the disease. CXL has been utilized for over a 10 year period and based on the evidence of efficacy and safety in the adult population; this treatment has been recently utilized in management of pediatric keratoconus. This article will present an update about current management of pediatric keratoconus with special focus on CXL in this age group. |
| Databáze: | Directory of Open Access Journals |
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