COMPUTER-AIDED PROTEIN DIRECTED EVOLUTION: A REVIEW OF WEB SERVERS, DATABASES AND OTHER COMPUTATIONAL TOOLS FOR PROTEIN ENGINEERING

Autor: Rajni Verma, Ulrich Schwaneberg, Danilo Roccatano
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Computational and Structural Biotechnology Journal, Vol 2, Iss 3 (2012)
Druh dokumentu: article
ISSN: 2001-0370
DOI: 10.5936/csbj.201209008
Popis: The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in this rapidly growing field. We will restrict ourselves to overview the availability, usability and limitations of web servers, databases and other computational tools proposed in the last five years. The goal of this review is to provide concise information about currently available computational resources to assist the design of directed evolution based protein engineering experiment.
Databáze: Directory of Open Access Journals