| Autor: |
Kazuto Oya, Kenji Sakuma, Satoru Esumi, Yasuhiko Hashimoto, Masakazu Hatano, Yuki Matsuda, Yuki Matsui, Nobumi Miyake, Ikuo Nomura, Makoto Okuya, Nakao Iwata, Masaki Kato, Ryota Hashimoto, Kazuo Mishima, Norio Watanabe, Taro Kishi |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Neuropsychopharmacology Reports, Vol 39, Iss 3, Pp 241-246 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2574-173X |
| DOI: |
10.1002/npr2.12056 |
| Popis: |
Abstract Aim Whether patients with adult bipolar disorder (BD) who have been clinically stabilized with lithium or lamotrigine should continue this medication is not established fully. This systematic review and meta‐analysis evaluated the efficacy and safety of lithium and lamotrigine for maintenance treatment in clinically stable patients with adult BD. Methods This meta‐analysis included only double‐blind, randomized, placebo‐controlled trials with an enrichment design that selected patients who responded acutely to lithium or lamotrigine. Reports prior to November 15, 2018, were retrieved from the PubMed/Cochrane Library/Embase. The primary outcome was the relapse rate due to any mood episode at the study endpoint. Other outcomes were relapse rates due to a manic/hypomanic/mixed episode or depression at the study endpoint, discontinuation rate, death, and death by suicide. Risk ratios (RRs) (95% confidence intervals) were calculated. When the random‐effects model showed significant differences between groups, the number‐needed‐to‐treat (NNT) was estimated. Results The search retrieved two studies regarding lithium (N = 218) and four evaluating lamotrigine (N = 706). Both drugs were superior to placebo for reducing the relapse rate due to any mood episode [lithium: RR = 0.52 (0.41‐0.66), P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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