Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Autor: Marc van Oostrum, Benjamin Campbell, Charlotte Seng, Maik Müller, Susanne tom Dieck, Jacqueline Hammer, Patrick G. A. Pedrioli, Csaba Földy, Shiva K. Tyagarajan, Bernd Wollscheid
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18494-6
Popis: Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemical long-term potentiation (cLTP), revealing surface proteome remodeling largely independent of global proteostasis.
Databáze: Directory of Open Access Journals