Effects of The Combination of Seluang Fish (Rasbora spp.) and Pasak Bumi (Eurycoma Longifolia Jack) on Systemic Inflammation and Neurotransmitter in Stunting Model Rat (Rattus Novergicus)
| Autor: | Didik Dwi Sanyoto, Hendra Nur'amin, Triawanti Triawanti, Dimas Ikhsan Airlangga, Gastin Gabriel Jangkang |
|---|---|
| Jazyk: | English<br />Indonesian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Magna Medika, Vol 10, Iss 1, Pp 27-39 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2407-0505 2774-2318 |
| DOI: | 10.26714/magnamed.10.1.2023.27-39 |
| Popis: | Background: Stunting causes growth and development issues which are characterized by a systemic inflammatory response and neurotransmitter disorder. The South Kalimantan natural resources i.e. extracts of Pasak Bumi (Eurycoma longifolia Jack) and seluang fish have the potential as a modified therapy for stunting management. Objective: To analyze the effect of Pasak Bumi and seluang fish administration in overcoming systemic inflammation and neurotransmitter disorders in the stunting rats model. Methods: Rats were divided into six group i.e Positive Control (KP): Stunting rats + placebo + standard feed; (P1): stunting rats + 70% EPB 15 mg/kg body weight (BW) + standard feed; (P2): Stunting rats + DHA 1 mg/kg BW + standard feed; (P3): Stunting rats + EPB 15 mg/kg BW + DHA 1 mg/kg BW + standard feed; (P4): Stunting rats + seluang fish; (P5): Stunting rats + EPB 15 mg/kg BW + seluang fish for 5 weeks; Parameters measured were levels of IL-6, TNF-α, and serotonin. Results: There were significant differences in levels of TNF-α (p = 0.000) and serotonin (p = 0.000). Conclusion: The administration of Pasak Bumi extract and seluang fish was able to inhibit systemic inflammation and neurotransmitter dysregulation. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|