Combination of pregabalin and Amitriptyline in management of chronic idiopathic pain following penile prosthesis implantation: a pilot study

Autor: Hassan Shaker, Nouran Omar El Said, Karim Omar ElSaeed
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Basic and Clinical Andrology, Vol 34, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 2051-4190
DOI: 10.1186/s12610-024-00223-4
Popis: Abstract Background Chronic post-penile prosthesis pain is de novo pain persisting > 2 months post-operatively. This pain is inadequately reported, poorly understood and undermanaged. The purpose of this current pilot study was to improvise a medical approach to alleviate the condition and assess the combination of Pregabalin and Amitriptyline in its management. Results The study enrolled 9 patients complaining of idiopathic penile, pelvic, or scrotal pain persisting > 2 months after penile prosthesis implantation. Patients were prescribed pregabalin 75mg/12h (escalated after 1 week to 150mg/12h upon demand) and Amitriptyline 25mg once daily for 3 months. The pain was reassessed after 10, 30 and 100 days. The dose of pregabalin required and the side effects of the medication were noted. Findings revealed a significant decrease in pain duration (p = 0.007), frequency (p
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