Salivary kallikrein-8 as a favorable biomarker for stress response
| Autor: | Semsi Rabia, Ergunol Erdal, Sepici Dincel Aylin |
|---|---|
| Jazyk: | English<br />Serbian |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Vojnosanitetski Pregled, Vol 81, Iss 7, Pp 447-451 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0042-8450 2406-0720 |
| DOI: | 10.2298/VSP231013038S |
| Popis: | Background/Aim. Kallikreins (KLKs) are a group of serine protease enzymes capable of cleaving protein peptide bonds. Besides, they are proteolytic enzymes that mediate the conversion of kininogen (alpha 2-globulin) to brady-kinin or kallidin. The aim of the study was to examine whether KLK8 might serve as a novel stress biomarker. Methods. Twenty-four students (17 female and 7 male) were included in the study. The general and dental health of the students were evaluated in the appropriate anamnesis format. Unstimulated samples were collected by Sarstedt® saliva collection tubes as recommended: 08.00–09.00 am, 12.00, and 2.00–3.00 pm on the exam day. KLK levels were measured by a KLK8 Human ELISA kit. Results. The salivary KLK8 levels in the morning (1.25 ± 0.26 pg/mL) were statistically significantly lower than the KLK8 levels pre-exam [at 12.00 (2.89 ± 0.85 pg/mL)] (p = 0.0006). There was also a significant difference in salivary KLK8 levels between pre- and post-exam (1.69 ± 0.39) time points (p = 0.0005). Conclusion. These results show that the differences in salivary KLK8 levels might be related to the degree of stress, indicating that KLK8 may serve as a novel stress biomarker. |
| Databáze: | Directory of Open Access Journals |
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