| Autor: |
Cheng-Hai Zhang, Yao Gao, Unmesh Jadhav, Han-Hwa Hung, Kristina M. Holton, Alan J. Grodzinsky, Ramesh A. Shivdasani, Andrew B. Lassar |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2399-3642 |
| DOI: |
10.1038/s42003-021-01857-0 |
| Popis: |
Zhang et al. identify Creb5 as a transcription factor that is required for induction of Prg4 expression by TGFβ and EGFR ligands. They show that Creb5 directly binds to two Prg4 promoter-proximal regulatory elements, working together with a more distal regulatory element to drive induction of Prg4 by TGFβ. These findings provide new insight into the molecular regulation of Prg4 expression in superficial zone articular chondrocytes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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