Cytokine profile associated with chronic and acute human schistosomiasis mansoni
| Autor: | Clarice Neuenschwander Lins de Morais, Joelma Rodrigues de Souza, Wlademir Gomes Melo, Marcílio L Aroucha, Paulo Miranda, Ana Lúcia Coutinho Domingues, Frederico Guilherme Coutinho Abath, Silvia Maria Lucena Montenegro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 103, Iss 6, Pp 561-568 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0074-0276 1678-8060 04386973 |
| DOI: | 10.1590/S0074-02762008000600009 |
| Popis: | The production and regulation of interleukin (IL) IL-13, IL-4 and interferon-gamma (IFN-³) was evaluated in 43 schistosomiasis patients with different clinical forms. Whole-blood cultures cytokine production in response to soluble egg antigen (SEA), soluble worm adult preparation (SWAP), mitogens, neutralizing antibodies or recombinant IL-13 were measured by ELISA. After SWAP stimulation, chronic patients, particularly hepatointestinals, produced higher levels of IL-4 in comparison with acute patients, suggesting the presence of a type 2 cytokine profile in these patients. Following SEA and SWAP stimulation, hepatosplenic (HS) patients showed increased levels of IFN-³ when compared with acute patients, indicating that HS disease in humans is associated with a type 1 cytokine response. The mechanisms of immune regulation are apparently different between the clinical stages of the disease, some of which are antigen-specific. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|