Role of Oxidative Stress on Malarial Anaemia: Significance of Oxidative Stress Index in Patients with Malarial Infection
| Autor: | Syed Ghouse Ali Hatim, DS Jagannadha Phaneendra, V Sampath Kumar, Sasikala Thallapaneni, Yericherla BD Suchetha |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | National Journal of Laboratory Medicine, Vol 11, Iss 01, Pp 04-06 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2277-8551 2455-6882 |
| DOI: | 10.7860/NJLM/2022/48961.2557 |
| Popis: | Introduction: An alteration of oxidant and antioxidant levels is thought to be involved in the pathogenesis of malaria. Limited data is found on association between oxidant and antioxidant status and significance of oxidative stress index in patients with malarial infection and anaemia in south Indian population. Aim: To measure the levels of oxidants and antioxidants and oxidative stress index in patients with malaria and their association with anaemia. Materials and Methods: The present case-control study was conducted in Department of Biochemistry, Osmania General Hospital, Hyderabad, India. A total of 50 subjects of malaria aged 20-45 years were included as cases based on inclusion criteria and exclusion criteria. Control group comprised of 50 healthy age and gender matched subjects. Haemoglobin (Hb), serum Malondialdehyde (MDA), Superoxide Dismutase (SOD), Total Antioxidant Capacity (TAC) was estimated in both the groups by standard methods using Ultraviolet Spectrophotometer. Independent sample t-test was used to test for the difference in all biochemical parameters among study and control groups. The study of orrelation among the parameters was done by Pearson’s correlation. Results: Both the groups were age and gender matched (p=0.39). MDA was significantly elevated in cases as compared to controls (p |
| Databáze: | Directory of Open Access Journals |
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