| Autor: |
Jerry O Adeyemi, Timothy O Ajiboye, Adebola O Oyedeji, Moganavelli Singh, Olaniyi A Fawole |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Nano Express, Vol 5, Iss 3, p 035004 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2632-959X |
| DOI: |
10.1088/2632-959X/ad5d80 |
| Popis: |
Although hematite (Fe _2 O _3 ) nanoparticles are gaining attention for biomedical purposes due to their unique properties, eco-friendly synthesis using plant extracts is being explored due to toxicity concerns of the resulting material. This study explores the use of plant extracts ( Dovyalis caffra leaf extracts) for the synthesis of Fe _2 O _3 nanoparticles alongside their cytotoxicity profile using human embryonic kidney cells (HEK293) and human cervical cancer cells (HeLa). The physicochemical properties of the prepared nanoparticles were established using x-ray diffraction (XRD) and microscopy techniques, confirming their crystalline nature and spherical morphology with minimal agglomeration. Using the MTT assay approach, the cytotoxicity profile of the nanoparticles revealed dose-dependent cytotoxic effects, with higher specificity towards cancer cells and very low toxicity towards the human cell line, suggesting safe usage as biomedical agents. While the standard drug 5-Fluorouracil possessed significantly higher cytotoxicity, its unwanted high toxicity towards normal human cells makes the Fe _2 O _3 nanoparticles a better choice. These findings suggest the potential of Dovyalis caffra leaf extract-mediated Fe _2 O _3 nanoparticles for biomedical applications, emphasizing their low toxicity towards normal human cells and specificity towards cancer cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
