Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation.

Autor: Kanwal Rehman, Syeda Mehak Munawar, Muhammad Sajid Hamid Akash, Manal Ali Buabeid, Tahir Ali Chohan, Muhammad Tariq, Komal Jabeen, El-Shaimaa A Arafa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: PLoS ONE, Vol 15, Iss 1, p e0227637 (2020)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0227637
Popis: Leptin resistance and co-existing insulin resistance is considered as hallmark of diet-induced obesity. Here, we investigated therapeutic potential of hesperidin to improve leptin and insulin resistance using high fat diet (HFD)-induced obese experimental animal model. We also performed in silico studies to validate therapeutic effectiveness of hesperidin by performing protein-ligand docking and molecular dynamics simulation studies. Group 1 was identified as control group receiving vehicle only. Group 2 was marked as non-treated group receiving 60% HFD. While, other groups were treated daily with orlistat (120 mg/kg/d), hesperidin (55 mg/kg/d), combination of hesperidin (55 mg/kg/d) + orlistat (120 mg/kg/d). Hesperidin alone (P
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